Intraoperative Near-infrared Imaging Can Identify Canine Mammary Tumors, a Spontaneously Occurring, Large Animal Model of Human Breast Cancer

ABSTRACT Introduction Current methods of intraoperative margin assessment in breast conserving surgery are impractical, unreliable, or time consuming. We hypothesized that intraoperative near-infrared (NIR) imaging with an FDA-approved NIR optical contrast agent could identify canine mammary tumors, a spontaneous large animal model of human breast cancer, during surgery. Methods Dogs with mammary tumors underwent a…

Evaluation Of Intraoperative Near-Infrared Fluorescence Visualization Of The Lung Tumor Margin With Indocyanine Green Inhalation

Question  Can an intraoperative near-infrared fluorescence imaging technique be used to detect lung tumor margin via inhalation delivery of indocyanine green? Findings  In this diagnostic study, the fluorescent signal of inhaled indocyanine green was observed throughout healthy lung tissue but was rarely detected in tumor tissue. Inhalation at a 20-fold lower dose of indocyanine green…

Indocyanine Green Fluorescence Imaging To Predict Graft Survival After Orthotopic Liver Transplantation: A Pilot Study

ABSTRACT Introduction: The incidence of primary non-function (PNF) after liver transplantation (LT) remains a major concern with the increasing use of marginal grafts. Indocyanine green (ICG) fluorescence is an imaging technique used in hepatobiliary surgery and LT. Because few early predictors are available, we aimed to quantify in real time the fluorescence of grafts during LT…

Use Of Indocyanine Green For Intraoperative Ureteral Identification In Nonurologic Surgery

We report the use of indocyanine green (ICG) for ureteral identification during nonurologic surgery. Indocyanine green is a cyanine-based dye that can be injected intravenously to visualize vascularized structures with near-infrared (NIR) fluorescence. Other reports suggest that intraureteral ICG instillation offers benefits for ureteral identification during urologic and nonurologic minimally invasive surgery.1,2 JAMA Surg. Published online…

A Study Investigating The Perfusion Of Colorectal Anastomoses Using Fluorescence Angiography: Results Of Flag Randomized Trial

Methods A single center randomized trial was undertaken between 2018 and 2019. Those patients who underwent a stapled colorectal anastomosis were randomized 1:1 for ICG FA vs. visual clinical assessment of blood perfusion of the anastomosed colon and rectal stump (non‐ICG FA group). The primary end‐point was to assess whether ICG FA was associated with…

Visualization And Quantification Of Anastomotic Perfusion In Colorectal Surgery Using Near-Infrared Fluorescence

ABSTRACT Background Anastomotic leakage (AL) is one of the most troublesome complications in colorectal surgery. Recently, near-infrared fluorescence (NIRF) imaging has been used intraoperatively to detect sentinel lymph nodes and visualize the blood supply at the region of interest (ROI). The aim of this study was to evaluate the role of visualization and quantification of…

NCI Drug Dictionary Adds Definition For Fluorescent Antibody SGM-101

FLUORESCENT ANTIBODY SGM-101 A near infrared-emitting fluorochrome-labeled anti-carcinoembryonic antigen (ACE; anti-CEA) monoclonal antibody, with potential diagnostic imaging activity. Upon administration, the fluorescent antibody SGM-101 binds CEA-overexpressing cancer cells. Upon fluorescence imaging, the fluorochrome can be visualized and CEA-overexpressing cancer cell can be imaged and detected. CEA, a tumor-associated antigen (TAA), is overexpressed on the surface…

SGM-101: An Innovative Near-Infrared Dye-Antibody Conjugate That Targets CEA For Fluorescence-Guided Surgery.

Abstract PURPOSE: Fluorescence-guided surgery (FGS) provides surgeons with new opportunities to improve real-time cancer nodule detection and tumor margin visualization. Currently, the most important challenge in this field is the development of fluorescent dyes that specifically target tumors. We developed, characterized and evaluated SGM-101, an innovative antibody-dye conjugate in which the fluorochrome BM104, which has…