Near-infrared Fluorescence Imaging for Sentinel Lymph Node Identification in Melanoma Surgery

Abstract Although less common than other types of skin cancers, melanoma is accountable for the majority of skin cancer-related deaths. The standard management for patients with clinically negative nodes includes a sentinel lymph node (SLN) biopsy, which is commonly performed using a combination of radioactive tracer (Tc-99) and a blue dye (isosulfan or patent blue).…

A Systematic Review of Concordance between Indocyanine Green and 99m Technetium Sentinel Lymph Node Identification in Melanoma

Stephanie L. Koonce*, Martin I. Newman University of Minnesota Medical School, USA *Corresponding author: Stephanie L. Koonce, University of Minnesota Medical School, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd., Weston, USA Published: 23 Jun, 2017 Cite this article as: Koonce SL, Newman MI. A Systematic Review of Concordance between Indocyanine Green and 99m Technetium Sentinel Lymph Node Identification…

Nerve spectroscopy: understanding peripheral nerve autofluorescence through photodynamics

Methods: Samples from various human peripheral nerves were selected postoperatively. Nerve fibers were divided into three groups: Group A nerve fibers were washed with a physiologic solution; Group B nerve fibers were fixated with formaldehyde for 6 h first, and then washed with a physiologic solution; Group C nerve fibers were fixated with formaldehyde for six…

Nerve autofluorescence in near-ultraviolet light markedly enhances nerve visualization in vivo

Methods: We exposed sciatic nerves within the posterior thigh in five 250-300 gm Wistar rats, then observed them at four different NUV intensity levels: 20%, 35%, 50%, and 100%. Brightness of fluorescence was measured by fluorescence spectroscopy, quantified as a fluorescence score using Image-J software, and statistically compared between nerves, background, and both an artery and…

Widespread anorectal lymphovascular networks and tissue drainage: analyses from submucosal india ink injection and indocyanine green fluorescence imaging

Methods In this descriptive study, we performed microanatomical evaluations and intraoperative imaging analysis in a cadaver and patients with rectal cancer. Specimens with India ink injection were collected from a cadaver and six patients who underwent abdominoperineal resection. Intraoperative indocyanine green fluorescence imaging was performed on four patients who underwent surgery for lower rectal cancer.…

Does Near-infrared Fluorescent Cholangiography with Indocyanine Green Reduce Bile Duct Injuries and Conversions to Open Surgery During Laparoscopic or Robotic Cholecystectomy?

Methods A thorough PubMed search was conducted to identify randomized clinical trials and nonrandomized clinical trials with ≥100 patients. Because all near-infrared fluorescent cholangiography studies were published since 2013, only studies without near-infrared fluorescent cholangiography published since 2013 were included for comparison. Incidence estimates, weighted and unweighted for study size, were adjusted for acute versus…

Artificial Intelligence Indocyanine Green (ICG) Perfusion for Colorectal Cancer Intra-operative Tissue Classification

METHODS Intraoperative white-light and NIR-fluorescence multispectral videos of primary colorectal tumours in patients undergoing diagnostic and therapeutic intervention were used for both AI model training and testing. These contained mucosal tumours subsequently determined as being benign or malignant with their surrounding area of macroscopically normal tissue, as viewed in both white light and NIR after…

Commentary On: Indocyanine Green does not Decrease the Need for Bail-out Operation in an Acute Care Surgery Population

The authors of this publication are to be commended for conducting this retrospective study analyzing the impact of near infrared fluorescent cholangiography (NIFC) in patients undergoing laparoscopic cholecystectomy (LC) for symptomatic or complicated cholelithiasis in an acute care setting. In this study, a total of 198 patients who underwent LC were evaluated. Acute cholecystitis was…

Consensus Conference Statement on the general use of Near-infrared Fluorescence Imaging and Indocyanine Green Guided Surgery Results of a Modified Delphi Study

Background: In recent decades, the use of near-infrared light and fluores- cence-guidance during open and laparoscopic surgery has exponentially expanded across various clinical settings. However, tremendous variability exists in how it is performed. Objective: In this first published survey of international experts on fluorescence-guided surgery, we sought to identify areas of consensus and non- consensus across 4…

Does Intraoperative Indocyanine Green Fluorescence Angiography Decrease the Incidence of Anastomotic Leakage in Colorectal Surgery? A Systematic Review and Meta-Analysis

ABSTRACT Background Colorectal anastomoses in patients with colorectal cancer carry a high risk of leakage. Indocyanine green fluorescence angiography (ICG-FA) is a new technique that allows surgeons to assess the blood perfusion of the anastomosis during operation. This meta-analysis aimed to evaluate whether ICG-FA could prevent anastomotic leakage (AL) in colorectal surgery. Methods Four databases…