The International Society For Fluorescence Guided Surgery (ISFGS)

Artificial Intelligence and Fluorescence Guided Surgery for Intraoperative Cancer Classification

Fluorescence guided surgery uses indocyanine green and near-infrared end-laparoscopy to visualise tissue perfusion. The specific characteristics of neoplasia including angiogenesis means differences in tissue behaviour to the dye can be exploited most efficiently if artificial intelligence methods (in particular bio-physics inspired modelling) are employed. Here we show this in action.


The initial clinical pilot is now published open access online in the British Journal of Surgery


The work is part of a research consortium comprising University College Dublin, The Royal College of Surgeons in Ireland, the Mater Misericordiae University Hospital and IBM Research in Europe and is …

Ureteral Identification Using ICG During Colorectal Procedures

A technique used to facilitate the anatomical identification of the ureter during colorectal surgeries

Image-guided pediatric patients using indocyanine green (ICG) fluorescence in minimally invasive surgery

Indocyanine green (ICG)-guided near-infrared fluorescence (NIRF) has been recently adopted in pediatric minimally invasive surgery (MIS). This video aimed to report our experience with ICG-guided NIRF in pediatric laparoscopy, thoracoscopy and robotics and evaluate its usefulness and technique of application in different pediatric pathologies.

ISFGS Announces Publication of Consensus on Fluorescence Guided Surgeries (FGS) in Annals of Surgery

The International Society for Fluorescence Guided Surgery (ISFGS), the leading organization dedicated to the global advancement of fluorescence-guided surgery, is pleased to announce the publication in Annals of Surgery, “Consensus Conference Statement on the general use of near-infrared fluorescence imaging and indocyanine green guided surgery: Results of a modified Delphi study”. 

“This publication confirms that fluorescence-guided surgeries will dramatically alter the way surgeries will be performed in future”, said lead author Raul J. Rosenthal MD FACS, Clinical Professor of Surgery at the Lerner College of Medicine at CWRU and Department Chairman of General Surgery at Cleveland Clinic in Weston, Florida. …

Defining Standards in Fluorescence Guided Endocrine Surgery

ISFGS brings you a new series of round table discussions with the experts of fluorescence guided surgery. 


View live recording here.

Near Infrared Fluorescent Guided Surgery for Brain Tumors with Dr. John Y. K. Lee

Dr. Lee is Associate Professor of Neurosurgery and Otolaryngology at the University of Pennsylvania. He has published extensively on fluorescent molecular imaging, and he specializes in minimally invasive neurosurgery including endoscopy and Gamma Knife radiosurgery.

In this video, Dr. Lee describes his five year experience with high dose, delayed indocyanine green (TumorGlowTM aka Second Window IcG) for brain tumors. The technique works best for contrast-enhancing tumors such as high grade gliomas, all brain metastasis, meningiomas, pituitary adenomas and other histologies. The technique has high sensitivity and high positive predictive value with excellent signal to noise as the brain's intact blood-brain …

Ureteral Identification with ICG During Colorectal Procedures

Fluorescence guided surgery technique used in ureteral identification.

Laparoscopic Cholecystectomy Guide Using ICG for Nurses and Healthcare Workers

6 things you need to know about Laparoscopic Cholecystectomy and how Fluorescence Guided Surgery can prevent bile duct injury when using ICG. Education for nurses and other affiliated health professionals working in settings where laparoscopic cholecystectomy is performed.

Colectomy using ICG: A 3D Visual Guide

A 3D animation showing how ICG works using fluorescence guided imaging during a colon resection.

3D Animation Visualization of Fluorescence Guided Imaging in Laparoscopic Cholecystectomy

How Indocyanine Green (ICG) is used for laparoscopic cholecystectomy. This 3D animation visualization shows a quick overview of how fluorescence guided surgery works for laparoscopic cholecystectomy. Understanding the ICG administration process.

How Fluorescence Works: A 3D Visual Guide

A 3D visualization animation on how fluorescence works. Learn about how the fluorescent dye, known as Indocyanine Green (ICG) works in the body.

Near Infrared Fluorescence Imaging of Lymphatic Disorders with Dr. Miguel Amore, MD, FACS

Lymphatic disorder is a malfunction of the lymphatic system in which fluid, or lymph, does not pass properly through the lymph nodes and lymphatic vessels. The most common lymphatic disease is lymphedema. The earlier lymphedema is treated, the more that can be done to prevent its progression. Near infrared fluorescence is useful to understand early physiopatgological changes of the lymphatic system after primary or secondary damage and that way an early treatment.

Tumor-Targeted Fluorescent Dyes for FGS Edited with Dr. Philip S. Low, MD

Complete surgical resection of all malignant tissue remains the most reliable cure for cancer. To facilitate quantitative removal of all cancer lesions, we have developed low molecular weight ligand-targeted fluorescent dyes that bind to receptors on cancer cells and thereby illuminate tumor tissue without highlighting normal tissue. With the aid of these dyes surgeons have been able to i) find and resect more malignant lesions, ii) detect and remove positive tumor margins, iii) more accurately stage cancer patients, and iv) locate and resect more malignant lymph nodes than was previously possible using standard surgical methods of palpation and visual inspection. …

Lymph node mapping in Colorectal Cancer Surgery with Dr. Gabriel Liberale

Nodal staging is a major prognostic factor in colorectal cancer (CRC) and is used to determine which patients should receive adjuvant chemotherapy. Sentinel lymph node (SLN) has been reported as the first lymph node (LN) receiving lymphatic drainage from the tumor as a consequence nodal staging of a patient can be predicted through analysis of this SLN. This concept has been applied in malignant melanoma and breast cancer, using peritumoral blue dye injection, where it has become the standard of care allowing to avoid unnecessary lymphadenectomy in node negative (pN0) patients. However, in colon cancer lymphadenectomy is systematically performed. Therefore, …