The International Society For Fluorescence Guided Surgery (ISFGS)

Dr. Lee is Associate Professor of Neurosurgery and Otolaryngology at the University of Pennsylvania. He has published extensively on fluorescent molecular imaging, and he specializes in minimally invasive neurosurgery including endoscopy and Gamma Knife radiosurgery.

In this video, Dr. Lee describes his five year experience with high dose, delayed indocyanine green (TumorGlowTM aka Second Window IcG) for brain tumors. The technique works best for contrast-enhancing tumors such as high grade gliomas, all brain metastasis, meningiomas, pituitary adenomas and other histologies. The technique has high sensitivity and high positive predictive value with excellent signal to noise as the brain's intact blood-brain barrier provides clean background preventing ICG extravasation into normal brain.