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Ureteric Localization with Indocyanine Green Fluorescence During Low Anterior Resection – A Video Vignette

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  • Título completo del paper: Ureteric localization with indocyanine green fluorescence during low anterior resection - a video vignette
  • Autores: A Vilar Tabanera, M Bajawi, P Abadía, A Puerta Vicente, A Ballestero, D Ramos, I Moreno, J D Pina, J Die
  • Fecha de publicacion: 2020-06-18
  • doi: https://doi.org/10.1111/codi.15158
Released: July 14th, 2020 08:25 PM Website: HTTPS://ONLINELIBRARY.WILEY.COM/DOI/FULL/10.1111/CODI.15158

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Intraoperative Near-infrared Imaging Can Identify Canine Mammary Tumors, a Spontaneously Occurring, Large Animal Model of Human Breast Cancer

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  • Título completo del paper: Intraoperative near-infrared imaging can identify canine mammary tumors, a spontaneously occurring, large animal model of human breast cancer
  • Autores: Andrew Newton, Jarrod Predina, Michael Mison, Jeffrey Runge, Charles Bradley, Darko Stefanovski, Sunil Singhal, David Holt
  • Fecha de publicacion: 2020-06-17
  • doi: https://doi.org/10.1371/journal.pone.0234791
ABSTRACT Introduction Current methods of intraoperative margin assessment in breast conserving surgery are impractical, unreliable, or time consuming. We hypothesized that intraoperative near-infrared (NIR) imaging with an FDA-approved NIR optical contrast agent could identify canine mammary tumors, a spontaneous large animal model of human breast cancer, during surgery. Methods Dogs with mammary tumors underwent a standard of care lumpectomy or mastectomy with wide surgical margins 20 hours after indocyanine green administration (3 mg/kg IV). During surgery, NIR imaging was performed on...

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Evaluation Of Intraoperative Near-Infrared Fluorescence Visualization Of The Lung Tumor Margin With Indocyanine Green Inhalation

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  • Título completo del paper: Evaluation of Intraoperative Near-Infrared Fluorescence Visualization of the Lung Tumor Margin With Indocyanine Green Inhalation
  • Autores: Yu Hua Quan, Chan Hee Oh, Daeho Jung 3, Ji-Young Lim, Byeong Hyeon Choi, Jiyun Rho, Yeonho Choi, Kook Nam Han, Beop-Min Kim, Chungyeul Kim, Ji-Ho Park, Hyun Koo Kim
  • Fecha de publicacion: 2020-08-01
  • doi: https://doi.org/10.1001/jamasurg.2020.1314
Question  Can an intraoperative near-infrared fluorescence imaging technique be used to detect lung tumor margin via inhalation delivery of indocyanine green? Findings  In this diagnostic study, the fluorescent signal of inhaled indocyanine green was observed throughout healthy lung tissue but was rarely detected in tumor tissue. Inhalation at a 20-fold lower dose of indocyanine green had a 2-fold higher efficiency for tumor margin detection compared with the intravenous injection of indocyanine green. Meaning  Image-guided surgery based on low-dose indocyanine green inhalation appears to...

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Indocyanine Green Fluorescence Imaging To Predict Graft Survival After Orthotopic Liver Transplantation: A Pilot Study

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  • Título completo del paper: Indocyanine Green Fluorescence Imaging to Predict Graft Survival After Orthotopic Liver Transplantation: A Pilot Study
  • Autores: Damien Dousse, Eric Vibert, Quentin Nicolas, Muga Terasawa, Luis Cano, Marc-Antoine Allard, Chady Salloum, Oriana Ciacio, Gabriella Pittau, Antonio Sa Cunha, Daniel Cherqui, René Adam, Didier Samuel, Irene Vignon-Clemente, Nicolas Golse
  • Fecha de publicacion: 2020-10-01
  • doi: https://doi.org/10.1002/lt.25796
ABSTRACT Introduction: The incidence of primary non-function (PNF) after liver transplantation (LT) remains a major concern with the increasing use of marginal grafts. Indocyanine green (ICG) fluorescence is an imaging technique used in hepatobiliary surgery and LT. Because few early predictors are available, we aimed to quantify in real time the fluorescence of grafts during LT to predict their 3 months survival. Patients and methods: After graft revascularization, ICG was intravenously injected, then the fluorescence of the graft was captured with a near infrared camera and...

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Use Of Indocyanine Green For Intraoperative Ureteral Identification In Nonurologic Surgery

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We report the use of indocyanine green (ICG) for ureteral identification during nonurologic surgery. Indocyanine green is a cyanine-based dye that can be injected intravenously to visualize vascularized structures with near-infrared (NIR) fluorescence. Other reports suggest that intraureteral ICG instillation offers benefits for ureteral identification during urologic and nonurologic minimally invasive surgery.1,2 JAMA Surg. Published online March 18, 2020. doi:10.1001/jamasurg.2020.0094 Released: March 23rd, 2020 08:39 AM...

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A Study Investigating The Perfusion Of Colorectal Anastomoses Using Fluorescence Angiography: Results Of Flag Randomized Trial

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  • Título completo del paper: A study investigating the perfusion of colorectal anastomoses using fluorescence angiography: results of the FLAG randomized trial
  • Autores: M Alekseev, E Rybakov, Y Shelygin , S Chernyshov, I Zarodnyuk
  • Fecha de publicacion: 2020-04-06
  • doi: https://doi.org/10.1111/codi.15037
Methods A single center randomized trial was undertaken between 2018 and 2019. Those patients who underwent a stapled colorectal anastomosis were randomized 1:1 for ICG FA vs. visual clinical assessment of blood perfusion of the anastomosed colon and rectal stump (non‐ICG FA group). The primary end‐point was to assess whether ICG FA was associated with a reduction in the incidence of AL . Secondary outcomes were rate of postoperative complications and change in the level of bowel resection. Results A total of 380 patients undergoing sigmoid and rectal resection were enrolled. After...

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Phase I Of Sgm-101 In Patients With Cancer Of The Colon, Rectum Or Pancreas

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Introduction: Surgery is the most important therapy for patients with cancer of the colon, rectum or pancreas. Complete resection, which is a crucial factor in the prognosis of a patient, is challenging as surgeons have to rely on visual appearance and palpation to discriminate between tumor and normal tissue. Carcinoembryonic antigen (CEA) is a tumor-specific marker that is highly expressed in a number of tumors of epithelial origin (such as colorectal carcinoma and pancreas carcinoma) while it is minimally expressed in normal adult tissues. The compound that will be studied in this...

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