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Phase I Of SGM-101 In Patients With Cancer Of The Colon, Rectum Or Pancreas

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Surgery is the most important therapy for patients with cancer of the colon, rectum or pancreas. Complete resection, which is a crucial factor in the prognosis of a patient, is challenging as surgeons have to rely on visual appearance and palpation to discriminate between tumor and normal tissue. Carcinoembryonic antigen (CEA) is a tumor-specific marker that is highly expressed in a number of tumors of epithelial origin (such as colorectal carcinoma and pancreas carcinoma) while it is minimally expressed in normal adult tissues. The compound that will be studied in this research...

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Randomized Controlled Trial Comparing White Light With Near-Infrared Autofluorescence For Parathyroid Gland Identification During Total Thyroidectomy

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  • Título completo del paper: Randomized Controlled Trial Comparing White Light With Near-Infrared Autofluorescence For Parathyroid Gland Identification During Total Thyroidectomy
  • Autores: Fernando Dip, Jorge Falco, Silvina Verna, Marcos Prunello, Matias Loccisano, Pablo Quadri, Kevin White, Raul Rosenthal
  • Fecha de publicacion: 2020-10-07
  • doi: https://doi.org/10.1016/j.jamcollsurg.2018.12.044
Abstract BACKGROUND: Parathyroid glands are difficult to identify during total thyroidectomies, and accidental resection can lead to problematic postoperative hypocalcemia. Our main goals were to evaluate the effectiveness of using near-infrared light (NIRL) autofluorescence intraoperatively for parathyroid gland identification and to measure its impact on postoperative hypocalcemia incidence. STUDY DESIGN: Total thyroidectomies were performed on 170 patients with different thyroid pathologies, block-randomized (1:1) into 2 equal groups. Among controls, traditional overhead...

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Randomized Trial Of Near-Infrared Incisionless Fluorescent Cholangiography

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  • Título completo del paper: Randomized Trial Of Near-Infrared Incisionless Fluorescent Cholangiography
  • Autores: Fernando Dip, Emanuelle LoMenzo, Luis Sarotto, Edward Phillips, Hernan Todeschini, Mario Nahmod, Lisandro Alle, Sylke Schneider, Ludwig Kaja, Luigi Boni, Pedro Ferraina, Thomas Carus, Norihiro Kokudo, Takeaki Ishizawa, Mathew Walsh, Conrad Simpfendorfer, Roy Mayank, Kevin White, Raul J. Rosenthal
  • Fecha de publicacion: 2019-09-04
  • doi: https://doi.org/10.1097/sla.0000000000003178
Abstract Background: Incisionless near-infrared fluorescent cholangiography (NIFC) is emerging as a promising tool to enhance the visualization of extrahepatic biliary structures during laparoscopic cholecystectomies. Methods: We conducted a single-blind, randomized, 2-arm trial comparing the efficacy of NIFC (n = 321) versus white light (WL) alone (n = 318) during laparoscopic cholecystectomy. Using the KARL STORZ Image1 S imaging system with OPAL1 technology for NIR/ICG imaging, we evaluated the detection rate for 7 biliary structures—cystic duct (CD), right hepatic duct...

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Transanal Total Mesorectal Excision For Rectal Cancer With Indocyanine Green Fluorescence Angiography

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  • Título completo del paper: Transanal total mesorectal excision for rectal cancer with indocyanine green fluorescence angiography
  • Autores: I Mizrahi, F B de Lacy, M Abu-Gazala, L M Fernandez, A Otero, D R Sands, A M Lacy, S D Wexner
  • Fecha de publicacion: 2018-10-01
  • doi: https://pubmed.ncbi.nlm.nih.gov/30430309/
Abstract BACKGROUND: The aim of this study was to evaluate the impact of fluorescence angiography (FA) on any change in proximal resection margin and/or anastomotic leak (AL) following transanal total mesorectal excision (TaTME) for rectal cancer (RC). METHODS: This retrospective cohort study was conducted at two centers by three senior surgeons. Both institutions' prospectively maintained Institutional Review Board-approved databases were retrospectively queried for all consecutive patients between July 2015 and May 2017 who had laparoscopic hybrid trans-abdominal total...

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Sensitivity And Specificity Of Indocyanine Green Near-Infrared Fluorescence Imaging In Detection Of Metastatic Lymph Nodes In Colorectal Cancer: Systematic Review And Meta-Analysis

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  • Título completo del paper: Sensitivity And Specificity Of Indocyanine Green Near-Infrared Fluorescence Imaging In Detection Of Metastatic Lymph Nodes In Colorectal Cancer: Systematic Review And Meta-Analysis
  • Autores: Sameh H Emile, Hossam Elfeki, Mostafa Shalaby, Ahmad Sakr, Pierpaolo Sileri, Søren Laurberg, Steven D Wexner
  • Fecha de publicacion: 2017-11-07
  • doi: https://doi.org/10.1002/jso.24701
Abstract This review aimed to determine the overall sensitivity and specificity of indocyanine green (ICG) near-infrared (NIR) fluorescence in sentinel lymph node (SLN) detection in Colorectal cancer (CRC). A systematic search in electronic databases was conducted. Twelve studies including 248 patients were reviewed. The median sensitivity, specificity, and accuracy rates were 73.7, 100, and 75.7. The pooled sensitivity and specificity rates were 71% and 84.6%. In conclusion, ICG-NIR fluorescence is a promising technique for detecting SLNs in CRC....

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Indocyanine Green Fluorescence Imaging In Colorectal Surgery: Overview, Applications, And Future Directions.

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  • Título completo del paper: Indocyanine Green Fluorescence Imaging In Colorectal Surgery: Overview, Applications, And Future Directions.
  • Autores: Deborah S Keller, Takeaki Ishizawa, Richard Cohen, Manish Chand
  • Fecha de publicacion: 2017-02-07
  • doi: https://doi.org/10.1016/s2468-1253(17)30216-9
Abstract Indocyanine green fluorescence imaging is a surgical tool with increasing applications in colorectal surgery. This tool has received acceptance in various surgical disciplines as a potential method to enhance surgical field visualisation, improve lymph node retrieval, and decrease the incidence of anastomotic leaks. In colorectal surgery specifically, small studies have shown that intraoperative fluorescence imaging is a safe and feasible method to assess anastomotic perfusion, and its use might affect the incidence of anastomotic leaks. Controlled trials are...

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Clinical Role Of Fluorescence Imaging In Colorectal Surgery - A Review

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Abstract Anastomotic leak (AL) after colorectal surgery is a devastating complication; decreased blood perfusion is an important risk factor. Surgeons rely on subjective measures to assess bowel perfusion. Fluorescence imaging (FI) with indocyanine green (ICG) provides a real-time objective assessment of intestinal perfusion. Areas covered: A PubMed search using the terms 'fluorescence imaging', 'indocyanine green', 'colon and rectal surgery' was undertaken. Sixteen articles between 2010 to present were identified. Main outcomes were leak rate reduction, change in surgical...

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