EMEA ICG Dosing for Vulvar Cancer
Indocyanine green (ICG) fluorescence imaging is increasingly used in vulvar cancer surgery for sentinel lymph node mapping and lymphatic visualization. This technique enables accurate identification of inguinal lymphatic drainage pathways, which are critical for staging and prognosis.
ICG-based near-infrared imaging has demonstrated detection rates comparable to conventional techniques such as technetium-99m and blue dye, while reducing procedural complexity and morbidity associated with extensive lymphadenectomy.
In the EMEA region, standardized dosing and timing protocols help ensure consistent fluorescence imaging and support precise, minimally invasive surgical approaches in vulvar cancer management.
Tissue identification
Region of interest | Lymphatic drainage and SLN |
Dose | 2 mL (0.125 mg/mL) |
Route | Peritumoral injection - four quadrants |
Injection time | 3-20 hr before procedure |
First ICG detection | After 10mins |
ICG Duration | Remains visible during procedure as it diffuses slowly via lymphatics |
Camera requirements | Open procedure |
References (full ref details at end of this guide doc) | 20. 2020, Deken et al., |
*Saline flush (10mL) recommended post I.V. administration of Verdye™ (ICG) Injection
Note: dose may need to be adjusted to take into account differences in the Near Infra-Red (NIR) camera system being used
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