Lymph Node Mapping in Colorectal Cancer Surgery with Dr. Gabriel La
EUROPEAN CHAPTER
SPEAKERS
Gabriel Liberale
CHAPTER
EUROPEAN CHAPTER
Nodal staging is a major prognostic factor in colorectal cancer (CRC) and is used to determine which patients should receive adjuvant chemotherapy. Sentinel lymph node (SLN) has been reported as the first lymph node (LN) receiving lymphatic drainage from the tumor as a consequence nodal staging of a patient can be predicted through analysis of this SLN. This concept has been applied in malignant melanoma and breast cancer, using peritumoral blue dye injection, where it has become the standard of care allowing to avoid unnecessary lymphadenectomy in node negative (pN0) patients. However, in colon cancer lymphadenectomy is systematically performed. Therefore, the concept has been used to focus pathological analysis on the most representative LN using serial section, IHC and/ or RT-PCR. Actually, SLN detection using standard blue technique is not widely used, partly because of variability of the reported sensitivity of the SLN technique. Indocyanine green fluorescence imaging (ICG-FI) has been reported as a promising technique in the detection of SLN in various tumors.
The purpose of the webinar is to give an overview of the results from published studies using ICG-FI for SLN detection in CRC and some technical aspects.
